Research in the Fish lab focuses on craniofacial development and evolution.
We investigate molecular, cellular, and developmental mechanisms generating phenotypic variation that contribute to both disease and evolution.
Learn more about bones!
Our work describing a new role for Satb2 in osteoblast proliferation is now online!
Satb2 is known to regulate differentiation in osteoblasts. Our new data show that Satb2 has an additional role in osteoblast proliferation and that it also regulates nuclear integrity. Read more here.
Dates for DBTW 2019 have been set
The 2019 Developmental Biology Teaching Workshop will be held July 16-20, 2019 at the University of Maine's Darling Marine Center. Check back here or on the Darling Marine Center webpage for registration updates.
New publication in genesis on variation in craniofacial development is now online!
Developmental processes regulate phenotypic variation. Our new review illustrates this concept by explaining how ribosomopathies and spliceosomopathies share similar molecular mechanisms and phenotypes. Read more here.
Second annual SATB2 family meeting
Thanks again to UAMS and Dr. Yuri Zarate for inviting me to talk to SAS patients and their families about our research on SATB2. A wonderful opportunity to interact with individuals most impacted by our work.
21st Annual Student Research & Community Engagement Symposium
All students in the Fish lab presented posters at the 2018 symposium. Congratulations to Ralph Saint Louis for winning the best undergraduate poster presentation award of the Kennedy College of Sciences. Caroline Nazaire additionally won the fan favorite poster prize! That's 2 years in a row for our lab winning both prizes!
Biology Meritorious Student Award 2018
Congratulations to Ralph Saint Louis for winning the Department for Biological Sciences' Meritorious Student Award!
Todd Dowrey defends his Honors Thesis
Congratulations to Todd Dowrey on the excellent defense of his Honors Thesis entitled, "Developmental mechanisms underlying phenotypic variation in Satb2-mediated craniofacial disease."
New publication on SATB2 and bone health is now online
SATB2-associated syndrome (SAS) causes skeletal abnormalities such as tibial bowing, osteomalacia, osteopenia or osteoporosis. In this paper, we describe the frequency of skeletal disorders, treatments, and recommendations for monitoring SAS patients. Read more about it here.
New publication in Seminars in Cell and Developmental Biology on craniofacial evolvability is now online!
Organizers are critical mediators of evolvability. This new review argues that the evolution of craniofacial organizers was critical to the origin of the jaw and its subsequent diversification. Read more here.
Our work on Fgf8 and nonlinearities in development is published in Nature Communications!
How do developmental systems buffer genetic perturbation? Our work on Fgf8 in craniofacial development sheds light on canalization in development. This publication is the result of an outstanding multi-lab collaboration. Find this publication online here.
New episode of Bone Lab Radio
Congratulations to Ralph St. Louis for his production of the latest episode of Bone Lab Radio, Mystery Skeleton.
SATB2-associated syndrome Family Meeting
The first annual international SATB2-associated syndrome conference for children and their families, clinicians, and researchers took place in Little Rock Arkansas, August 3-5, 2017. At this event, Dr. Fish presented current research on SATB2 function and dysfunction in disease to families. Learn more about SATB2-associated syndrome here.
Outstanding Graduate Student Award 2017
Congratulations to Rachel Master for winning the Department for Biological Sciences' Outstanding Graduate Student Award!
2017 NESDB Meeting
Dr. Fish, Rachel Master, Fjodor Merkuri, Ralph Saint Louis and Evelyn Schwager presented the lab's research at this year's Northeast regional meeting of the Society of Developmental Biology in Woods Hole, MA.
20th Annual Student Research & Community Engagement Symposium
Several Fish lab members presented posters at this years' symposium. Congratulations to Fjodor Merkuri and Rachel Master for winning the best poster presentation award of the Kennedy College of Sciences. Rachel Master additionally won the fan favorite poster prize!
We congratulate Katie Dolan, who received her Master's degree.
We congratulate 3 lab members who graduated this year. Rachel Master received her Bachelor's degree and Deboshree Chakrabarti and Kristyne Giambino both received Master's degrees.
2016 NESDB meeting
Dr. Fish, Rachel Master, and Katie Dolan represented the lab at this year's Northeast regional meeting of the Society of Developmental Biology in Woods Hole, MA.
19th Annual Student Research Symposium
The Fish Laboratory presented research at this event.
With another year beginning, work in the lab continues. We look forward to welcoming new and old students!